Monitor Carefully (two)pentobarbital will lessen the extent or impact of suvorexant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Potent CYP3A4 inducers may possibly decrease suvorexant efficacy; if greater suvorexant dose needed, never exceed 20 mg/dayMonitor Closely (one)pentobarbital will enhance the amount or infl